It is a well known principle in 4-dimensional topology that homeomorphic smooth simply-connected 4-manifolds become diffeomorphic after 'stabilizing' by connected summing with S^2 x S^2 sufficiently many times. In fact many explicit examples are known for which exactly one stabilization is required, and surprisingly, no examples have been shown to require more than one. Perhaps this exoticity dissolves quickly under stabilization. An analogous principle holds for 2-spheres embedded in a simply-connected 4-manifold, namely, any two that are topologically isotopic become smoothly isotopic after stabilizing the manifold sufficiently many times. Until now, however, bounds on the number of stabilizations needed have not been found for any examples. In this talk, we will describe families of topologically isotopic knots that are not smoothly isotopic, but become so after one stabilization. This is joint work with Auckly, Kim and Ruberman.